Pemphigus Vulgaris (PV)
What is pemphigus vulgaris?
PV is a rare, chronic and severe disorder where patients develop blisters in the mucous membranes (which include the linings of the mouth, nose and eyes) and skin.
In PV, the immune system produces IgG antibodies that mistakenly attack structures (called desmogleins) that hold skin cells together.
This can cause skin cells to separate and fluid to collect between the layers of skin, forming blisters.
PV blisters can cause severe pain, itching and burning, significant damage to the skin and can sometimes lead to life-threatening fluid loss or infection.